Determining the Theoretical Rate of HDAC3 Inhibition Using PDA106 in Humans

by Abigail Sy

Submitted : Spring 2019

Multiple Sclerosis (MS) is a disease where the immune system attacks the body’s own neurons by destroying the myelin sheath, a protective covering.  A study found that inhibiting HDAC3 resulted in remyelination, essentially reversing the damage (He, et al, 2018).   This study, however, was conducted by fully inhibiting HDAC3 in mice.  In order to help find this as a possible treatment for humans with MS, this paper finds a theoretical minimum amount of inhibition.  HDAC3 is naturally in the body and it must not be healthy to have all of it inhibited considering it must have a function.  By using indefinite integrals to find the first order rate reaction and deriving the Michaelis-Menten Equation, a minimum rate was found.  Hopefully, future studies can determine if HDAC3 inhibition is a safe treatment for MS.  

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