Correlation Between Early Onset of Alzheimer's Disease and Ɛ4 Allele of Apolipoprotein E

by Rajesh Melaram

Submitted : Spring 2012

Alzheimer’s disease is a disease in which millions of people suffer from every day (Roses). The progression of Alzheimer’s disease is caused by a few mechanisms and they include: mutations in genes produced apolipoprotein E, reduced levels of neurotransmitter acetylcholine, and the disruption of inflow and outflow in calcium into and out of neurons. A study of 104 patients was used in order to find a correlation between the numbers of apolipoprotein alleles present in the late-onset patients and MRI changes in Alzheimer’s disease. The Pearson Product-Moment Correlation Coefficient was computed (0.18) to find no significant correlation between the two variables.

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