| Title | Vascular Dynamics of the Central Nervous System: Macro- and Micro-circulation |
| Speaker | Apurva Bhatty |
| Time | 2:00-3:00 p.m. |
| Place | LIF 267 |
Abstract
Cardiovascular dynamics has been modeled at many scales: from the computational
fluid dynamics approach at the smallest scales of fluid flow within the vasculature
to the lumped parameter simplified circuits at the larger scale of system dynamics.
The parameter values of such a circuit including the cerebro-vacular system may be derived from MRI images and from invasive and noninvasive clinical means. An approach combining 4th order Runge-Kutta simulation of the macro and microcirculation with cellular-automata-like diffusion modeling of metabolites within the microcirculation will be described along with clinical and research applications of this approach in the surgical operating theater and in aviation and space medicine.
| Title | Competition in host-parasitoid systems |
| Speaker | Professor Gary Huxel Department of Biology |
| Time | 2:00-3:00 p.m. |
| Place | LIF 267 |
Abstract
The Nicholson-Bailey host-parasitoid model system is inherently unstable. Factors such as spatial heterogeneity and density-dependent population growth can stabilize this system. However, the role of competition among both hosts and parasitoids in the N-B model system is largely unknown. We explore the consequences on stability and invasibility in low dimensional N-B model systems with multiple hosts and parasitoids.
| Title | Effects of turbulence on nutrient uptake by the benthos |
| Speaker | Professor Florence Thomas Department of Biology |
| Time | 2:00-3:00 p.m. |
| Place | LIF 267 |
Abstract
TBA.
| Title | Bonds between Proteins and Carbohydrates: Directing molecular dynamics inside and outside cells |
| Speaker | Anna Plaas Department of Internal Medicine |
| Time | 2:00-3:00 p.m. |
| Place | LIF 267 |
Abstract
The pivotal role of post-translational glycosylation of proteins for intracellular sorting, secretion, control of function and metabolic clearance, and modulation of protein/protein interactions involved in signal transduction pathways, is well documented. Thus, structure-function data of N- and O-linked oligosaccharides is now generally incorporated into proteomic and metabolomic thinking and experimentation.
The biological importance of another type of protein-carbohydrate bonding,
the non-covalent association of polysaccharides, glycosaminoglycans (GAGs),
with many extracellular proteins, includ- ing growth factors and morphogens
(FGF, HGF, chemokines, wnts), matrix proteins (collagen, fibronectin, link
glycoprotein), enzymes
(lipoprotein lipase, aggrecanase) and transmembrane proteins (CD44, HARE) has
recently drawn much research attention. These interactions are usually multivalent,
and an increasing number of complimentary amino acid and monosaccharide sequences
are being elucidated. They serve to regulate intracellular signal output of
receptor tyrosine kinases and extracellular modification of storage, diffusion
and concentration of protein effectors. In addition, multi-component processes
of cell-cell and cell-matrix interactions in epithelial- mesenchymal transition
in development and in malignancy have also been shown to be critically dependant
on the presence of GAG-protein interactions.
Please direct questions to mthmaster@nosferatu.cas.usf.edu.
Last updated: 14-Apr-2004.
Copyright © 2000, USF Department of Mathematics.